Two Harvard professors lobbed a bombshell last month in the London Review of Books with their article on The Israeli Lobby and American Foreign Policy. Their thesis is that we Americans have been hoodwinked into aligning ourselves so closely with Israel that we are no longer acting in the interest of the United States. Predictably the usual suspects are launching scathing personal attacks on the two professors and charges of Anti-Semitism rather than engage in honest debate. The article from the London Review of Books: The Israeli Lobby. If you can't access it here is the original Working Paper (PDF) published at Harvard University.
Wikipedia has a good overview of the debate.
The Nation takes it on in this week's issue: "Ferment over Israeli Lobby"